Formulation and evaluation of felodipine in softgels with solubilized core
- In: SIG Bioavailability / Bioequivalence - Poster Session
- At: Cairo (Egypt) (2005)
- Type: Poster
- Poster code: BB-P-013
- By: ABOUL-EINIEN, Mona (Faculty of Pharmacy, Cairo, Egypt)
Felodipine, an antihypertensive and antianginal calcium channel antagonist, is considered to be water insoluble ( about 1mg/L) and only 15% bioavailable. In this study softgels, with solubilized- drug core, were used to improve the solubility of felodipine. Drug solutions were prepared using both cosolvency and micellar solubilization.
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