Formulation and evaluation of felodipine in softgels with solubilized core

• In: SIG Bioavailability / Bioequivalence - Poster Session
• At: Cairo (Egypt) (2005)
• Type: Poster
• Poster code: BB-P-013
• By: ABOUL-EINIEN, Mona (Faculty of Pharmacy, Cairo, Egypt)
• Abstract:

  Felodipine, an antihypertensive and antianginal calcium channel antagonist, is considered to be water insoluble ( about 1mg/L) and only 15% bioavailable. In this study softgels, with solubilized- drug core, were used to improve the solubility of felodipine. Drug solutions were prepared using both cosolvency and micellar solubilization.
  
  The..

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