Preparation and in vivo efficacy of insulin-containing enteric microspheres
- At: 2010 FIP Congress in Lisbon (Portugal)
- Type: Poster
- By: CHANG, Li-Chien (National Defense Medical Center, Taipei, China Taiwan)
- Co-author(s): Chio, Yi-Chen (National Defense Medical Center, TAIPEI, China Taiwan)
Chua, Anna Chian New (National Defense Medical Center, TAIPEI, China Taiwan)
Purpose: This work is to evaluate the feasibility of combining cell-penetrating peptide (CPP) and enteric coating strategies for oral insulin delivery. Methods: The CPP-modified insulin was synthesized by covalent linkage of a cell-penetrating peptide-low molecular weight protamine (LMWP) with insulin. Insulin and the modified insulin were.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.