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Pharmacogenomic evaluation of gamma-glutamyl hydrolase in japanese healthy volunteers

  • At: 2010 FIP Congress in Lisbon (Portugal)
  • Type: Poster
  • By: NISHIMURA, Nobuhiro (Shimane University Hospital, Izumo, Japan)
  • Co-author(s): Hosogai, Tomomi (Shimane University Hospital, IZUMO, Japan)
    Hara, Yukari (Shimane University Hospital, IZUMO, Japan)
    Naora, Kohji (Shimane University Hospital, IZUMO, Japan)
  • Abstract:

    Purpose: Methotrexate (MTX) is widely used for the treatment of acute lymphoblastic leukemia and other malignant diseases. MTX is intracellularly metabolized to its more active forms, methotrexate polyglutamates, which are subsequently cleaved in lysosomes by gamma-glutamyl hydrolase (GGH). GGH is reported to act as key enzyme exhibiting

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Last update 4 October 2019

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