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Penetration of methotrexate into the cerebrospinal fluids after the high dose infusion in patients with malignant lymphoma

  • At: 2010 FIP Congress in Lisbon (Portugal)
  • Type: Poster
  • By: SUZUKI, Yosuke (Department of Clinical Pharmacy, Oita University Hospital, Yufu-shi, Japan)
  • Co-author(s): Itoh, Hiroki (Department of Clinical Pharmacy, Oita University Hospital, YUFU-SHI, Japan)
    Nishimura, Fumihiro (Department of Clinical Pharmacy, Oita University Hospital, YUFU-SHI, Japan)
    Abe, Tomohide (Department of Clinical Pharmacy, Oita University Hospital, YUFU-SHI, Japan)
    Sato, Yuhki (Department of Clinical Pharmacy, Oita University Hospital, YUFU-SHI, Japan)
    Takeyama, Masaharu (Department of Clinical Pharmacy, Oita University Hospital, YUFU-SHI, Japan)
  • Abstract:

    [INTRODUCTION]

    Therapeutic drug monitoring of the serum methotrexate (MTX) is often conducted to prevent toxicity after the high dose MTX infusion, however, time course of the cerebrospinal fluids (CSF) concentration of MTX is not known well. In this study, we evaluated the penetration of MTX into the CSF after the high dose MTX infusion in..

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Last update 4 October 2019

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