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Improved solubility and cellular uptake of paclitaxel using surface-modified solid lipid nanoparticles with hydrophilic derivative cyclodextrin

  • At: 2010 FIP Congress in Lisbon (Portugal)
  • Type: Poster
  • By: CHO, Cheong-Weon (Chungnam National University, Daejeon, South-Korea)
  • Co-author(s): Baek, Jong-Suep (Chungnam National University, DAEJEON, South-Korea)
    So, Jae-Woo (Chungnam National University, DAEJEON, South-Korea)
    Hwang, Ji-Sook (Chungnam National University, DAEJEON, South-Korea)
    Shin, Sang-Chul (Chonnam National University, GWANGJU, South-Korea)
  • Abstract:

    Paclitaxel (PTX), the first of a new class of microtubule stabilizing agents, is recognized as an effective chemotherapeutic agent for a wide variety of solid tumors. Clinical application of this highly effective drug in the treatment of cancer is limited because of its poor aqueous solubility and poor oral bioavailability. Therefore,..

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Last update 4 October 2019

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