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Involvement of mitochondrial swelling in cytochrome c release from mitochondria treated with calcium and alloxan

  • At: 2010 FIP Congress in Lisbon (Portugal)
  • Type: Poster
  • By: SAKURAI, Koichi (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
  • Co-author(s): Ichimura, Takuya (Hokkaido Pharmaceutical University School of Pharmacy, OTARU, Japan)
    Takahashi, Kiyoshi (Hokkaido Pharmaceutical University School of Pharmacy, OTARU, Japan)
    Ito, Mika (Hokkaido Pharmaceutical University School of Pharmacy, OTARU, Japan)
    Oyama, Kyohei (Hokkaido Pharmaceutical University School of Pharmacy, OTARU, Japan)
  • Abstract:

    An early event in the induction of apoptosis is cytochrome <i>c</i> (Cyt <i>c</i>) release from mitochondria. Alloxan has the cytotoxicity on pancreatic beta-cells and thus causes type 1 diabetes mellitus. Although the mechanism of cytotoxicity is not yet clearly understood, alloxan causes mitochondrial inner membrane permeability transition (MPT) ..

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Last update 4 October 2019

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