Salbutamol sulfate in-situ nasal gelling systems: formulation and evaluation
- At: 2010 FIP Congress in Lisbon (Portugal)
- Type: Poster
- By: ETMAN, Mohamed (Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt)
- Co-author(s): Farid, Ragwa (Faculty of Pharmacy and Drug manufacturing ,Pharos University, ALEXANDRIA, Egypt)
Ebian, Abdel-Azim (Faculty of Pharmacy, University of Alexandria, ALEXANDRIA, Egypt)
Nada, Aly (Faculty of Pharmacy, Kuwait University, SAFAT, Kuwait)
Introduction: Oral salbutamol undergoes first-pass metabolism. Nasal delivery could protect drugs from this effect. Mucoadhesive in-situ gels for salbutamol sulfate (SS) with gellan gum were formulated and tested in rats.
Methods: SS in-situ gels (2% w/w) were prepared at concentration of gellan gum 0.2%, 0.4% and 0.8% w/v with methyl paraben.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.