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Active metabolites formed during hepatic first-pass: simulations featuring their contribution to the overall effect in altered liver clearance and drug-drug interactions

  • At: 2009 FIP Congress in Istanbul (Turkey)
  • Type: Poster
  • By: ABDELAZIZ, Ahmed (German University in Cairo, Cairo, Egypt)
  • Co-author(s): Alaraby, Mohammad (German University in Cairo, CAIRO, Egypt)
    Mahran, Laila (German University in Cairo, CAIRO, Egypt)
    Spahn-Langguth, Hilde (University of Graz, GRAZ, Austria)
  • Abstract:

    Phase-I- and - occasionally - also phase-II metabolites may contribute to the overall effect of a drug. This is not always apparent or revealed, since total concentrations of metabolites may be low in relation to parent drug concentrations. In the case of carvedilol, using a comparison of HPLC and beta 1-specific radioligand-receptor-binding assay ..

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Last update 4 October 2019

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