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Effect of CYP2C19 and CYP2C9 genotype on concentration prediction of valproate in epileptic patients

  • At: 2009 FIP Congress in Istanbul (Turkey)
  • Type: Poster
  • By: JIANG, Dechun (Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing, China)
  • Co-author(s): Bai, Xiangrong (Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing, China)
    Zhang, Qingxia (Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing, China)
    Lu, Wei (School of Pharmaceutical Science,Peking University, Beijing, China)
    Wang, Yuqin (Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing, China)
    Li, Lin (Department of Pharmacology, Xuan-wu Hospital of Capital Medical University, Educ, Beijing, China)
  • Abstract:

    Objective: To study the effect of CYP2C19 and CYP2C9 genotype on concentration prediction of valproate in epileptic patients, and to promote individualized therapy.
    Method: The VPA concentrations of 110 epileptic patients, who were monotherapy by VPA, were collected. The genotype of CYP2C19*2, CYP2C19*3 and CYP2C9*3 were examined by polymerase

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Last update 4 October 2019

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