Determination of blood methotrexate polyglutamates by liquid chromatography/tandem mass spectrometry after low-dose methotrexate therapy in patients with rheumatoid arthritis

• At: 2009 FIP Congress in Istanbul (Turkey)
• Type: Poster
• By: MO, Xiaolan (The First Affliated Hospital, Sun Yat-sun University, Guangzhou, China)
• Co-author(s): Ren, Bin (The First Affliated Hospital, Sun Yat-sun University, GUANGZHOU, China)
  Chen, Xiao (The First Affliated Hospital, Sun Yat-sun University, GUANGZHOU, China)
  Wen, Yuguan (Guangzhou Brain Hospital, GUANGZHOU, China)
  
• Abstract:

  Methotrexate (MTX) is currently one of the most widely used drug for the treatment of rheumatoid arthritis , which may produce antiarthritic effects through polyglutamation to methotrexate polyglutamates (MTXPGs) , a process that attaches sequential γ-linked glutamic residues to MTX.A rapid and sensitive LC/MS/MS method was developed for the..

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