Determination of blood methotrexate polyglutamates by liquid chromatography/tandem mass spectrometry after low-dose methotrexate therapy in patients with rheumatoid arthritis
- At: 2009 FIP Congress in Istanbul (Turkey)
- Type: Poster
- By: MO, Xiaolan (The First Affliated Hospital, Sun Yat-sun University, Guangzhou, China)
- Co-author(s): Ren, Bin (The First Affliated Hospital, Sun Yat-sun University, GUANGZHOU, China)
Chen, Xiao (The First Affliated Hospital, Sun Yat-sun University, GUANGZHOU, China)
Wen, Yuguan (Guangzhou Brain Hospital, GUANGZHOU, China)
Methotrexate (MTX) is currently one of the most widely used drug for the treatment of rheumatoid arthritis , which may produce antiarthritic effects through polyglutamation to methotrexate polyglutamates (MTXPGs) , a process that attaches sequential Î³-linked glutamic residues to MTX.A rapid and sensitive LC/MS/MS method was developed for the.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.