Disk intrinsic dissolution to monitor polymorphism and morphology of carbamazepine raw drug material

• At: 2009 FIP Congress in Istanbul (Turkey)
• Type: Presentations + Posters
• By: FLICKER, Felicia (Industrial Pharmacy Lab, University of Basel, Basel, Switzerland)
• Co-author(s): Sehic, Selma (Bosnalijek d.d. Development Department, Sarajevo, Bosnia and Herzegovina)
  Betz, Gabriele (Industrial Pharmacy Lab, University of Basel, Basel, Switzerland)
  
• Abstract:

  Background. Carbamazepine (CBZ), a poorly water soluble antiepileptic drug with dissolution controlled bioavailability, exhibits at least 4 polymorphic forms and 1 dihydrate. During dissolution in water CBZ anhydrates transform to dihydrate. This transformation was found to be a critical parameter in the still persisting unexpected dissolution

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