Disk intrinsic dissolution to monitor polymorphism and morphology of carbamazepine raw drug material

• In: G1 - The 10 best industrial pharmacy contributions of 2009 on Saturday, 5 September 2009, 9:15-11:40
• At: Istanbul (Turkey) (2009)
• Type: Presentations + Posters
• By: FLICKER, Felicia (Industrial Pharmacy Lab, University of Basel, Basel, Switzerland)
• Co-author(s): Sehic, Selma (Bosnalijek d.d. Development Department, Sarajevo, Bosnia and Herzegovina)
  Betz, Gabriele (Industrial Pharmacy Lab, University of Basel, Basel, Switzerland)
  
• Abstract:

  Background. Carbamazepine (CBZ), a poorly water soluble antiepileptic drug with dissolution controlled bioavailability, exhibits at least 4 polymorphic forms and 1 dihydrate. During dissolution in water CBZ anhydrates transform to dihydrate. This transformation was found to be a critical parameter in the still persisting unexpected dissolution

  ..

The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress. Please login