Disk intrinsic dissolution to monitor polymorphism and morphology of carbamazepine raw drug material
- At: 2009 FIP Congress in Istanbul (Turkey)
- Type: Presentations + Posters
- By: FLICKER, Felicia (Industrial Pharmacy Lab, University of Basel, Basel, Switzerland)
- Co-author(s): Sehic, Selma (Bosnalijek d.d. Development Department, Sarajevo, Bosnia and Herzegovina)
Betz, Gabriele (Industrial Pharmacy Lab, University of Basel, Basel, Switzerland)
Background. Carbamazepine (CBZ), a poorly water soluble antiepileptic drug with dissolution controlled bioavailability, exhibits at least 4 polymorphic forms and 1 dihydrate. During dissolution in water CBZ anhydrates transform to dihydrate. This transformation was found to be a critical parameter in the still persisting unexpected dissolution.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.