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Differences in cytochrome p450 and nuclear receptor mrna levels in liver and small intestines between sd and da rats

  • At: 2009 FIP Congress in Istanbul (Turkey)
  • Type: Poster
  • By: MASAHIRO, Iwaki (Kinki University, Osaka, Japan)
  • Co-author(s): Atsushi, Kawase (Kinki University, OSAKA, Japan)
    Akiyuki, Fujii (Kinki University, OSAKA, Japan)
    Ryosuke, Akai (Kinki University, OSAKA, Japan)
  • Abstract:

    This study aimed to clarify the differences in mRNA levels of cytochrome P450 (CYP) isoforms and nuclear receptors between Dark Agouti (DA) and Sprague-Dawley (SD) rats which are animal models for poor metabolizers and extensive metabolizers for CYP2D6, respectively. Using liver and small intestine tissues of both rat strains, we investigated the ..

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Last update 4 October 2019

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