Investigation of melatonin absorption mechanism by pharmaceutical excipients using the ussing chamber technique

• In: Biopharmaceutics Classification System - Posters
• At: Istanbul (Turkey) (2009)
• Type: Poster
• Poster code: BCS-P-002
• By: LEE, Beom-Jin (College of Pharmacy, Kangwon National University, Chuncheon, South-Korea)
• Co-author(s): Tran, Huyen (College of Pharmacy, Kangwon National University, CHUNCHEON, South-Korea)
  Tran, Phuong (College of Pharmacy, Kangwon National University, CHUNCHEON, South-Korea)
  Tran, Thao (College of Pharmacy, Kangwon National University, CHUNCHEON, South-Korea)
  Chun, Inkoo (College of Pharmacy, Dongduk Women’s University, SEOUL, South-Korea)
  
• Abstract:

  We examined melatonin absorption and its modulation mechanism by pharmaceutical excipients (sodium cholate, sodium oleate) using the Ussing chamber technique. Melatonin absorption occurs throughout the GI tract but can be classified as a low permeability drug. P-glycoprotein does not affect melatonin absorption but transported rhodamine 123, a..

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