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Piperazinediones and inhibitory activity against human breast cancer

  • At: 2009 FIP Congress in Istanbul (Turkey)
  • Type: Poster
  • By: WANG, Hui-po (Taipei Medical University, Taipei, China Taiwan)
  • Co-author(s): Wang, Chuin-Li (Taipei Medical University, Taipei, China Taiwan)
    Tseng, Yufeng J. (Graduate Institute of Biomedical Electronics & Bioinformatics, National Taiwan U, Taipei, China Taiwan)
    Wu, Tong-Rung (Graduate Institute of Biomedical Electronics & Bioinformatics, National Taiwan U, Taipei, China Taiwan)
    Guh, Jih-Hwa (School of Pharmacy, National Taiwan University, Taipei, China Taiwan)
  • Abstract:

    Purpose: Thirty piperazinediones (HPW99s) were synthesized for targeting to protein tyrosine kinases. Cytotoxicity of the analogues were screened on MDA-MB-231 human breast cancer cell line. QSAR analysis, based on the inhibition data of the lead compound TW01 (HPW99-5) on protein tyrosine kinases, for constructing a receptor-independent model for

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Last update 4 October 2019

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