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Pharmacokinetics study of irinotecan and sn-38 by coadministered thalidomide in rat

  • At: 2009 FIP Congress in Istanbul (Turkey)
  • Type: Poster
  • By: SHI, Aixin (Department of pharmacy, Beijing Hospital, Beijing, China)
  • Co-author(s): Hu, Yanling (Department of pharmacy, Beijing Hospital, Beijing, China)
    Hu, Xin (Department of pharmacy, Beijing Hospital, Beijing, China)
    Sun, Chunhua (Department of pharmacy, Beijing Hospital, Beijing, China)
  • Abstract:

    BACKGROUND: Irinotecan(CPT-11) is a broad-spectrum antineoplastic agent The clinical use of CPT-11 is hindered by dose-limiting diarrhea. SN-38 is an active metabolite of CPT-11, delayed diarrhea could be reduced if the concentration of SN-38 was decreased. It has been confirmed the intestinal toxicity of CPT-11 was relieved by coadministrated

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Last update 4 October 2019

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