Pharmacokinetics study of irinotecan and sn-38 by coadministered thalidomide in rat

• In: Laboratory and Medicines Control Services - Posters
• At: Istanbul (Turkey) (2009)
• Type: Poster
• Poster code: LMCS-P-008
• By: SHI, Aixin (Department of pharmacy, Beijing Hospital, Beijing, China)
• Co-author(s): Hu, Yanling (Department of pharmacy, Beijing Hospital, Beijing, China)
  Hu, Xin (Department of pharmacy, Beijing Hospital, Beijing, China)
  Sun, Chunhua (Department of pharmacy, Beijing Hospital, Beijing, China)
  
• Abstract:

  BACKGROUND: Irinotecan(CPT-11) is a broad-spectrum antineoplastic agent The clinical use of CPT-11 is hindered by dose-limiting diarrhea. SN-38 is an active metabolite of CPT-11, delayed diarrhea could be reduced if the concentration of SN-38 was decreased. It has been confirmed the intestinal toxicity of CPT-11 was relieved by coadministrated

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