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Enhanced oral bioavailability of flurbiprofen by the combined use of polysorbate 80 and ?-cyclodextrin

  • At: 2009 FIP Congress in Istanbul (Turkey)
  • Type: Poster
  • By: YONG, Chul Soon (College of Pharmacy, Yeungnam University, Gyeongsangbuk-do, South-Korea)
  • Co-author(s): Lee, Won Seok (College of Pharmacy, Yeungnam University, GYEONGSANGBUK-DO, South-Korea)
    Han, Myo Jeong (College of Pharmacy, Yeungnam University, GYEONGSANGBUK-DO, South-Korea)
    Yoo, Bong Kyu (College of Pharmacy, Yeungnam University, GYEONGSANGBUK-DO, South-Korea)
    Woo, Jong Soo (College of Pharmacy, Yeungnam University, GYEONGSANGBUK-DO, South-Korea)
    Lee, Young-Im (College of Pharmacy, Yeungnam University, GYEONGSANGBUK-DO, South-Korea)
    Choi, Han-Gon (College of Pharmacy, Yeungnam University, GYEONGSANGBUK-DO, South-Korea)
  • Abstract:

    The main objective of this study was to study the effect of the mixed system containing surfactant micelle and -cyclodextrin on the solubility of poorly water-soluble drug flurbiprofen, and evaluate its in vitro and in vivo performance. The mixed system was characterized by solubility study and phase solubility study in -cyclodextrin,..

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Last update 4 October 2019

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