Influence of enterohepatic circulation on bioequivalence evaluation of cyproterone acetate 100 mg tablets in healthy volunteers

• In: SIG: Bioavailability/Bioequivalence - Posters
• At: Basel (Switzerland) (2008)
• Type: Poster
• Poster code: BB-P-022
• By: PORTA, Valentina (College of Pharmaceutical Sciences, University of São Paulo, SÃo Paulo, Brazil)
• Co-author(s): Ching, Rute Chuang Kuei (College of Pharmaceutical Sciences, University of São Paulo, SÃO PAULO, Brazil)
  Kano, Eunice Kazue (College of Pharmaceutical Sciences, University of São Paulo, SÃO PAULO, Brazil)
  Schramm, Simone Grigoleto (College of Pharmaceutical Sciences, University of São Paulo, SÃO PAULO, Brazil)
  Koono, Eunice Emiko Mori (College of Pharmaceutical Sciences, University of São Paulo, SÃO PAULO, Brazil)
  Ching, Ting Hui (College of Pharmaceutical Sciences, University of São Paulo, SÃO PAULO, Brazil)
  Serra, Cristina Helena dos Reis (College of Pharmaceutical Sciences, University of São Paulo, SÃO PAULO, Brazil)
  
• Abstract:

  Cyproterone plasmatic profile after oral administration to healthy volunteers presents two peaks, probably as a result of an enterohepatic recirculation process. According to some authors, the value of the area under the curve (AUC) should be corrected for drugs that undergo enterohepatic recirculation. The aim of the present study was to evaluate ..

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