Rational design of heat shock protein (hsp-70) inhibitors
- At: Seville (Spain) (2022)
- Type: Poster
- Poster code: NMS-035
- By: SHOEMAKE, Claire ()
- Co-author(s): Mr Laurent Grech, Pharmacy
Dr Claire Shoemake, Senior Lecturer
The Heat shock protein 70 (HSP-70) has a cytoprotective role against tumour necrosis factor alpha apoptosis, enhancing cancer cell survival. HSP-70 is often overexpressed in triple negative breast cancer (TNBC) cells. Various small molecule inhibitors targeting different TNBC survival pathways are in clinical trial phases.
This study was a first.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.