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Intestinal absorption of the prodrug Olmesartan Medoxomil is enhanced by oatp2b1-mediated uptake

  • At: Seville (Spain) (2022)
  • Type: Poster
  • Poster code: DDD-010
  • By: FUKAZAWA, Naomi (Keio University, Japan)
  • Co-author(s): Ms Naomi Fukazawa, Faculty of Pharmacy (Keio University, Minato-ku, Japan)
    Dr Saki Noguchi (Keio University, Minato-ku, Japan)
    Dr Tomohiro Nishimura (Keio University, Minato-ku, Japan)
    Professor Masatoshi Tomi (Keio University, Minato-ku, Japan)
  • Abstract:

    Background: Ester-prodrugs generally have a neutral charge at physiological pH and are orally absorbed via passive diffusion in the small intestine. Olmesartan medoxomil (OL-MX), an ester-prodrug of olmesartan (OL), is an oral approved-drug of angiotensin II receptor blockers (ARBs) and presents in the form of anions at intestinal pH. Organic..

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Last update 28 September 2023

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