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Impact of viscosity and pH of dissolution medium on ethanol-induced dose dumping from sodium alginate matrix tablets

  • At: Seville (Spain) (2022)
  • Type: Poster
  • Poster code: DDD-001
  • By: AL-ZOUBI, Nizar (The Hashemite University, Jordan)
  • Co-author(s): Prof Nizar Al-Zoubi, Dean (The Hashemite University, Zarqa, Jordan)
    Dr. Safwan Abdel Rahim, Department of Pharmaceutical Sciences and Pharmaceutics (Applied Science Private University, Amman, Jordan)
    Dr. Heba Khader, Department of Clinical Pharmacy and Pharmacy Practice (The Hashemite University, Zarqa, Jordan)
    Ms. Rahaf Alwaraydat, Department of Pharmaceutics and Pharmaceutical Technology (The Hashemite University, Zarqa, Jordan)
    Dr. Faisal Al-Akayleh, Department of Pharmaceutics and Pharmaceutical Technology (Petra University, Amman, Jordan)
  • Abstract:

    The release kinetics of oral modified-release (MR) formulations can change if concomitantly ingested with alcoholic beverages. This may lead to unfavorable changes in the drug bioavailability. The FDA requests in vitro dissolution of MR products in the presence of 5, 20, and 40% ethanol in 0.1N HCl for 2 h. However, there is limited..

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Last update 28 September 2023

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