THE EFFECT OF PROBIOTICS ON FUNCTIONAL CONSTIPATION IN THE ELDERLY
- At: PPR 2022 (2022)
- Type: Poster
- By: FEHIR ŠOLA, Katarina (EPhEU)
- Co-author(s): Katarina Fehir Šola, President, Pharmacy Bjelovar, Croatia
Donatella Verbanac, professor, Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia
Sanda Vladimir Knežević
Constipation is a common gastrointestinal complaint. Clinical research suggests that probiotics may improve people's condition of constipation. Therefore, this study aimed to examine the impact of selected strains of probiotics on the functional constipation of elderly placed in a nursing home, using a randomized, double-blind, placebo-controlled, parallel study design. Participants in the probiotic study were randomized into two groups over 12 weeks of intervention with probiotic strains of Bifidobacterium animalis subsp. lactis BLC1, Lactobacillus acidophilus LA 3, Lactobacillus casei BGP93 or placebo. The primary objective was to examine the effect of selected probiotic strains on the number of daily stools over 12 weeks. Secondary objectives of the study included assessing the effect of selected probiotic strains on markers of inflammation, glucose and lipid metabolism indicators, liver enzymes and other laboratory parameters of complete blood count, as well as the effect of pharmacy interventions on improving therapeutic outcomes and quality of life of elderly with functional constipation in a nursery home. After 12 weeks of treatment, the cumulative stool count increased continuously compared with placebo, but without statistical significance. However, excluding stool count data on days when laxative use was recorded, statistical significance was reached on day 71 of treatment. There, was no significant changes in blood parameters. Pharmacy interventions were an essential part of pharmaceutical care in a nursing home.