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Stevenson Johnson syndrome caused by enzalutamine: a case report

  • At: PPR SIG 2021 (2021)
  • Type: Digital
  • By: DENG, Min (Shenyang Pharmaceutical University, China)
  • Co-author(s): Min DENG
  • Abstract:

    Introduction

    Enzalutamide, a novel androgen receptor(AR) inhibitor, has been approved for the treatment of castration-resistant prostate cancer (CRPC) in many countries. The binding of enzalutamide to the AR prevents the nuclear translocation of the receptor, thus inhibiting the interaction between AR and DNA. The most reported adverse events are febrile neutropenia, hot flashes, hypertension and fatigue. However, the cutaneous adverse events is very rare.

    Objectives

    To explore pharmaceutical care for cutaneous adverse events induced by enzalutamide.

    Methods

    A case of Stevenson Johnson syndrome (SJS) induced by enzalutamide was reported. The clinical characteristics and treatment principles of the disease were analyzed in combination with literatures.

    Results

    Complete resolution of skin lesions and improvement of clinical symptoms occurred after three weeks.

    Conclusion

    Most of cutaneous adverse events may occur early during enzalutamide therapy, and close observation should be given within two weeks. In case there were cutaneous adverse events, proper symptomatic treatment should be provided, so as to reduce the occurrence of serious adverse events.

Last update 4 October 2019

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