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DICLOFENAC INDUCED LIVER INJURY IN HEPATOCYTES CO-CULTURED WITH MACROPHAGES

  • At: 2019 FIP Congress in AbuDhabi (United Arab Emirates)
  • Type: Poster
  • By: KAWASE, Atsushi (Kindai University, Japan)
  • Co-author(s): Atsushi Kawase: Department of Pharmacy, Kindai University, Osaka, Japan
    Rio Yamashita: Department of Pharmacy, Kindai University, Osaka, Japan
    Hiroaki Shimada: Department of Pharmacy, Kindai University, Osaka, Japan
    Masahiro Iwaki: Department of Pharmacy, Kindai University, Osaka, Japan
  • Abstract:

    Background

    Reactive metabolites of diclofenac (DIC) such as DIC acyl-β-D-glucuronide (DIC-AG) form the covalent protein binding in hepatocytes (HC) following a decrease of protein function or inducing an immune response. However, the precise mechanisms of drug-induced liver injury (DILI) remain unclear. This lack of mechanistic understanding makes..

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Last update 21 September 2019

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