EARLY HEMODIALYSIS IMPROVED CLINICAL OUTCOMES IN A CASE OF LIFE-THREATENING VALPROIC ACID POISONING

• At: AbuDhabi (United Arab Emirates) (2019)
• Type: Poster
• Poster code: POS-HPS-025
• By: LEE, Ching-Fen (Chang Gung Memorial Hospital-Linkou, Tao-yuan ,Taiwan, Division of Clinical Pharmacy, Department of Pharmacy, China Taiwan)
• Co-author(s): Ching-Fen Lee: Division of Clinical Pharmacy, Department of Pharmacy, Chang Gung Memorial Hospital-Linkou, Tao-yuan , Taiwan, Taoyuan, China Taiwan
  Shin-Tarng Deng: Division of Clinical Pharmacy, Department of Pharmacy, Chang Gung Memorial Hospital-Linkou, Tao-yuan , Taiwan, Taoyuan, China Taiwan
  Tzu-Cheng Tsai: Division of Clinical Pharmacy, Department of Pharmacy, Chang Gung Memorial Hospital-Linkou, Tao-yuan , Taiwan, Taoyuan, China Taiwan
  
• Abstract:

  Background

  Valproic acid (VPA) is used as an antiepileptic drug and a mood stabilizer. Therapeutic serum concentrations of VPA range from 50 to 100 mg/L. Levels > 450 mg/L have been found to cause severe life-threatening clinical manifestations such as severe central nervous system (CNS) depression, hyperammonemia, and cerebral edema which can be..

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