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EARLY HEMODIALYSIS IMPROVED CLINICAL OUTCOMES IN A CASE OF LIFE-THREATENING VALPROIC ACID POISONING

  • At: 2019 FIP Congress in AbuDhabi (United Arab Emirates)
  • Type: Poster
  • By: LEE, Ching-Fen (Chang Gung Memorial Hospital-Linkou, Tao-yuan ,Taiwan, Division of Clinical Pharmacy, Department of Pharmacy, China Taiwan)
  • Co-author(s): Ching-Fen Lee: Division of Clinical Pharmacy, Department of Pharmacy, Chang Gung Memorial Hospital-Linkou, Tao-yuan , Taiwan, Taoyuan, China Taiwan
    Shin-Tarng Deng: Division of Clinical Pharmacy, Department of Pharmacy, Chang Gung Memorial Hospital-Linkou, Tao-yuan , Taiwan, Taoyuan, China Taiwan
    Tzu-Cheng Tsai: Division of Clinical Pharmacy, Department of Pharmacy, Chang Gung Memorial Hospital-Linkou, Tao-yuan , Taiwan, Taoyuan, China Taiwan
  • Abstract:

    Background

    Valproic acid (VPA) is used as an antiepileptic drug and a mood stabilizer. Therapeutic serum concentrations of VPA range from 50 to 100 mg/L. Levels > 450 mg/L have been found to cause severe life-threatening clinical manifestations such as severe central nervous system (CNS) depression, hyperammonemia, and cerebral edema which can be..

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Last update 13 May 2019

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