DEVELOPMENT RESEARCH USING DRUG DISCOVERY TOOLS AND LARGE-SCALE MEDICAL INFORMATION

• At: AbuDhabi (United Arab Emirates) (2019)
• Type: Poster
• Poster code: POS-DDD-014
• By: ZAMAMI, Yoshito (Tokushima University Graduate School of Biomedical Sciences, Clinical Pharmacology and Therapeutics, Japan)
• Co-author(s): Yoshito Zamami: Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan;Pharmacy, Tokushima University Hospital, Tokushima, Japan
  Yuki Izawa-Ishizawa: AWA Support Center, Tokushima University, Tokushima, Japan
  Takahiro Niimura: Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan
  Mitsuhiro Goda: Pharmacy, Tokushima University Hospital, Tokushima, Japan
  Naoto Okada: Pharmacy, Tokushima University Hospital, Tokushima, Japan
  Kenshi Takechi: Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan
  Masayuki Chuma: Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan
  Keijo Fukushima: Pharmacology for Life Sciences, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan
  Yuya Horinouchi: Pharmacology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan
  Yasumasa Ikeda: Pharmacology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan
  Hiromichi Fujino: Pharmacology for Life Sciences, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan
  Koichiro Tsuchiya: Medical Pharmacology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan
  Keisuke Ishizawa: Clinical Pharmacology and Therapeutics, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan;Pharmacy, Tokushima University Hospital, Tokushima, Japan
  
• Abstract:

  Background

  Oxaliplatin causes oxaliplatin-induced peripheral neuropathy (OIPN) as a side effect that reduces the patient's quality of life.Therefore, the development of preventive agents against OIPN is an Important research area.

  Methods

  We searched for candidate drugs that counteract changes in gene expression related to OIPN using LINCS, a drug
  ..

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