RATIONAL DESIGN OF LIVER X RECEPTOR (LXR) MODULATORS USING THE AGONIST GW3965 SCAFFOLD AS A LEAD

• At: AbuDhabi (United Arab Emirates) (2019)
• Type: Poster
• Poster code: POS-DDD-013
• By: SHOEMAKE, Claire (University of Malta, Pharmacy, Malta)
• Co-author(s): Nicole Bonello: Pharmacy, University of Malta, Msida, Malta
  Claire Shoemake: Pharmacy, University of Malta, Msida, Malta
  
• Abstract:

  Background

  Pancreatic cancer, probably due to characteristic late diagnosis, is associated with high mortality. The Liver-X_Receptor (LXR) is a druggable target for the development of agonists that could mitigate pancreatic cancer development. Literature indicates that experimental molecules GW3965 and 4-(3-Aryloxyaryl) quinoline sulfone have LXR..

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