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DESIGN OF PROTEIN KINASE INHIBITORS USING THE NATURALLY OCCURRING ISOJACAREUBIN SCAFFOLD AS A LEAD

  • At: 2019 FIP Congress in AbuDhabi (United Arab Emirates)
  • Type: Poster
  • By: SHOEMAKE, Claire (University of Malta, Pharmacy, Malta)
  • Co-author(s): Jeanelle Caruana: Pharmacy, University of Malta, Msida, Malta
    Claire Shoemake: Pharmacy, University of Malta, Msida, Malta
  • Abstract:

    Background

    Protein Kinase C (PKc) is a druggable target for the mitigation of proliferative malignant disease. Isojacareubin (ISJ) is a naturally occurring molecule that has been shown to be a high affinity PKc antagonist.

    Methods

    X-ray crystallographic deposition 2IOE describing the holo- bisindolylmaleimide (BIM) inhibitor:PKc complex was

    ..

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Last update 21 September 2019

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