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DESIGN OF PROTEIN KINASE INHIBITORS USING THE NATURALLY OCCURRING ISOJACAREUBIN SCAFFOLD AS A LEAD
- At: 2019 FIP Congress in AbuDhabi (United Arab Emirates)
- Type: Poster
- By: SHOEMAKE, Claire (University of Malta, Pharmacy, Malta)
- Co-author(s): Jeanelle Caruana: Pharmacy, University of Malta, Msida, Malta
Claire Shoemake: Pharmacy, University of Malta, Msida, Malta
BackgroundProtein Kinase C (PKc) is a druggable target for the mitigation of proliferative malignant disease. Isojacareubin (ISJ) is a naturally occurring molecule that has been shown to be a high affinity PKc antagonist.
X-ray crystallographic deposition 2IOE describing the holo- bisindolylmaleimide (BIM) inhibitor:PKc complex was.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.
Last update 21 September 2019