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DESIGN OF PROTEIN KINASE INHIBITORS USING STAUROSPORINE AS A LEAD

  • At: 2019 FIP Congress in AbuDhabi (United Arab Emirates)
  • Type: Poster
  • By: SHOEMAKE, Claire (University of Malta, Pharmacy, Malta)
  • Co-author(s): Elena Mallia: Pharmacy, University of Malta, Msida, Malta
    Claire Shoemake: Pharmacy, University of Malta, Msida, Malta
  • Abstract:

    Background

    The protein kinase C (PKc) family is a target in cancer management. PKc inhibitors have an important role in cancer chemotherapy1. Staurosporine, isolated from Streptomyces staurosporeus is an ATP-competitive kinase inhibitor capable of inducing cellular apoptosis2.

    Methods

    PDB crystallographic deposition 1STC describing the bound

    ..

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Last update 4 October 2019

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