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DESIGN OF BETA CELL LYMPHOMA-2 (BCL-2) RECEPTOR ANTAGONISTS AS CHEMOTHERAPEUTIC AGENTS

  • At: 2019 FIP Congress in AbuDhabi (United Arab Emirates)
  • Type: Poster
  • By: SHOEMAKE, Claire (University of Malta, Pharmacy, Malta)
  • Co-author(s): Yvonne Savona Ventura: Pharmacy, University of Malta, Msida, Malta
    Claire Shoemake: Pharmacy, University of Malta, Msida, Malta
  • Abstract:

    Background

    The Beta Cell Lymphoma-2 (BCL-2) receptor is a prosurvival protein. It is consequently a target in the design of molecules capable of restoring cells' to perform apoptosis. Navitoclax and venetoclax are BCL-2 antagonists, but are associated with thrombocytopaenic side-effects.

    Methods

    A virtual screening approach was adopted. Bioactive

    ..

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Last update 13 May 2019

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