DESIGN OF BETA CELL LYMPHOMA-2 (BCL-2) RECEPTOR ANTAGONISTS AS CHEMOTHERAPEUTIC AGENTS

• At: AbuDhabi (United Arab Emirates) (2019)
• Type: Poster
• By: SHOEMAKE, Claire (University of Malta, Pharmacy, Malta)
• Co-author(s): Yvonne Savona Ventura: Pharmacy, University of Malta, Msida, Malta
  Claire Shoemake: Pharmacy, University of Malta, Msida, Malta
  
• Abstract:

  Background

  The Beta Cell Lymphoma-2 (BCL-2) receptor is a prosurvival protein. It is consequently a target in the design of molecules capable of restoring cells' to perform apoptosis. Navitoclax and venetoclax are BCL-2 antagonists, but are associated with thrombocytopaenic side-effects.

  Methods

  A virtual screening approach was adopted. Bioactive

  ..

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