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DESIGN AND SYNTHESIS OF NEW SULFAMATE DERIVATIVES AS POTENTIAL STEROID SULFATASE ENZYME INHIBITORS

  • At: 2019 FIP Congress in AbuDhabi (United Arab Emirates)
  • Type: Poster
  • By: EL-GAMAL, Mohammed (United Arab Emirates)
  • Co-author(s): Mohammed El-Gamal: Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates
    Seyed-Omar Zaraei: Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates
    Paul Foster: Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates;, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TT, United Kingdom, Birmingham, United Kingdom
    Raafat El-Awady: DEPARTMENT OF PHARMACY PRACTICE AND PHARMACOTHERAPEUTICS, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates
    Barry Potter: DEPARTMENT OF PHARMACY PRACTICE AND PHARMACOTHERAPEUTICS, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates;Department of Pharmacology, University of Oxford, Oxford, United Kingdom
  • Abstract:

    Background

    The steroid sulfatase (STS) enzyme catalyzes the hydrolysis of inactive sulfate metabolites such as estrone sulfate and dehydroepiandrosterone sulfate to the more active estrone and dehydroepiandrosterone, respectively. Thus, STS is an attractive target for the treatment of hormone-dependent breast, endometrial,prostate cancers, and

    ..

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Last update 4 October 2019

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