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VOLUMETRIC ABSORTIVE MICROSAMPLING: NEW BLOOD COLLECTION METHOD FOR QUANTIFICATION OF TAMOXIFEN

  • At: 2019 FIP Congress in AbuDhabi (United Arab Emirates)
  • Type: Poster
  • By: MAGGADANI, Baitha (Universitas Indonesia, Pharmacy, Indonesia)
  • Co-author(s): Baitha palanggatan Maggadani: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
    Yahdiana harahap: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
    Harmita Harmita: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
    Marcellino ryan rinaldy: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
    Christoffel William Putra Untu: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
  • Abstract:

    Background

    Tamoxifen (TAM) is clinically proven to reduce breast cancer recurrence by blocking estrogen receptor, mainly through its active metabolites, endoxifen (END)and 4-hydroxytamoxifen (4HT) [1]. However, END level showed high variability between patients, widely based on CYP2D6 genetic polymorphism status [2].

    Methods

    20 µL of blood added with

    ..

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Last update 21 September 2019

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