VOLUMETRIC ABSORTIVE MICROSAMPLING: NEW BLOOD COLLECTION METHOD FOR QUANTIFICATION OF TAMOXIFEN

• At: AbuDhabi (United Arab Emirates) (2019)
• Type: Poster
• Poster code: POS-ASP-005
• By: MAGGADANI, Baitha (Universitas Indonesia, Pharmacy, Indonesia)
• Co-author(s): Baitha palanggatan Maggadani: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
  Yahdiana harahap: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
  Harmita Harmita: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
  Marcellino ryan rinaldy: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
  Christoffel William Putra Untu: Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia
  
• Abstract:

  Background

  Tamoxifen (TAM) is clinically proven to reduce breast cancer recurrence by blocking estrogen receptor, mainly through its active metabolites, endoxifen (END)and 4-hydroxytamoxifen (4HT) [1]. However, END level showed high variability between patients, widely based on CYP2D6 genetic polymorphism status [2].

  Methods

  20 µL of blood added with
  ..

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