Slco1b1 genetic polymorphisms in cardiac patients on simvastatin

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: CERDá IñESTA, Judith (University of Malta, Department of Pharmacy)
  • Co-author(s): Judith Cerdá Iñesta: Department of Pharmacy, University of Malta, Msida, Malta
    Francesca Wirth: Department of Pharmacy, University of Malta, Msida, Malta
    Graziella Zahra: Department of Pathology, Mater Dei Hospital, Msida, Malta
    Robert G. Xuereb: Department of Cardiology, Mater Dei Hospital, Msida, Malta
    Christopher Barbara: Department of Pathology, Mater Dei Hospital, Msida, Malta
    Anthony Serracino-Inglott: Department of Pharmacy, University of Malta, Msida, Malta
  • Abstract:

    Background

    Single nucleotide polymorphisms in the SLCO1B1 gene are associated with higher serum simvastatin concentrations and increased risk of simvastatin-induced myopathy (SIM).

    Methods

    Patients on simvastatin undergoing a procedure at the cardiac catheterisation suite in an acute general hospital were recruited into this cohort study after ethics

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