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Pharmacokinetics and pharmacodynamics of new purine-2,6-dione–based pde4/7 inhibitors in rats

  • At: Glasgow (Scotland) (2018)
  • Type: Poster
  • Poster code: POS-PAA-015
  • By: WYSKA, Elzbieta (Jagiellonian University Medical College, Department of Pharmacokinetics and Physical Pharmacy)
  • Co-author(s): Elżbieta Wyska
    Artur Świerczek: Department of Pharmacokinetics and Physical Pharmacy, Jagiellonian University Medical College, Kraków, Poland
    Krzysztof Pociecha: Department of Pharmacokinetics and Physical Pharmacy, Jagiellonian University Medical College, Kraków, Poland
    Marietta Ślusarczyk: Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland
    Agnieszka Jankowska: Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland
    Grażyna Chłoń-Rzepa: Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland
    Maciej Pawłowski: Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland
  • Abstract:

    Background

    Rheumatoid arthritis (RA) is a debilitating autoimmune disorder for which no fully effective treatment exists. The encouraging results of preclinical studies on selective phosphodiesterase (PDE) 4 inhibitors using animal models of this disease has prompted us to search for new antirheumatic compounds acting as dual PDE inhibitors that

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Last update 28 September 2023

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