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Pharmacokinetic-pharmacodynamic analyses of glimepiride using rats, and simulations of the effect

  • At: Glasgow (Scotland) (2018)
  • Type: Poster
  • Poster code: POS-PAA-006
  • By: KIRIYAMA, Akiko (Doshisha Women’s College of Liberal Arts, Faculty of Pharmaceutical Sciences)
  • Co-author(s): Akiko Kiriyama: Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts, Kyotanabe, Japan
    Shunsuke Kimura: Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts, Kyotanabe, Japan
    Akiko Tanaka: Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Kobe, Japan
    Toshiyasu Sakane: Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Kobe, Japan
    Katsumi Iga: Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts, Kyotanabe, Japan
  • Abstract:

    Background

    "EN-US">Efficacy/safety of a drug and its plasma concentration are closely correlated. Therefore, it is important to understand the relationship between the drug’s plasma concentration and its effects.

    Methods

    Glimepiride (0.2, 0.5 and 1.0 mg/kg) was intravenously infused for 30 min and blood samples were collected until 300 min for PK and

    ..

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Last update 28 September 2023

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