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Conformational studies of [3.3.1]azabicycles, synthetic analogues of norditerpenoid alkaloids

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: ZENG, Ziyu (University of Bath, Pharmacy and Pharmacology)
  • Co-author(s): Ziyu Zeng: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
    Michael Rowan: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
    Ian Blagbrough: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
  • Abstract:

    Background

    Functional group substituents on cyclohexane (A) and piperidine (E) rings in the hexacyclic norditerpenoids isolated from Aconitum and Delphinium are key to the biological activities of these alkaloids.

    Methods

    Double Mannich reactions were used to synthesize the [3.3.1]azabicycles and then derivatives, e.g. 2,4-DNP, were prepared. The

    ..

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Last update 13 May 2019

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