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Conformational studies of [3.3.1]azabicycles, synthetic analogues of norditerpenoid alkaloids
- At: 2018 FIP Congress in Glasgow (Scotland)
- Type: Poster
- By: ZENG, Ziyu (University of Bath, Pharmacy and Pharmacology)
- Co-author(s): Ziyu Zeng: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
Michael Rowan: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
Ian Blagbrough: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
BackgroundFunctional group substituents on cyclohexane (A) and piperidine (E) rings in the hexacyclic norditerpenoids isolated from Aconitum and Delphinium are key to the biological activities of these alkaloids.
MethodsDouble Mannich reactions were used to synthesize the [3.3.1]azabicycles and then derivatives, e.g. 2,4-DNP, were prepared. The.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.
Last update 13 May 2019