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Pristimerin regulates lipid biogenesis and mtor pathway by activating ampk in colon cancer cells

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: YOUSEF, Bashir (Faculty of Pharmacy, University of Khartoum, Department of Pharmacology)
  • Co-author(s): Bashir Alsiddig Yousef
    Hozeifa Hassan
    Luyong Zhang
    Zhenzhou Jiang
  • Abstract:

    Background

    Reprogramming of metabolic pathways and enhancements of lipid biogenesis are important features of colorectal cancer cells (CRC). AMP protein kinase (AMPK) is a metabolic sensor that modulates lipid biosynthetic enzymes and mTOR signaling pathway. Pristimerin, a naturally occurring triterpenoid was previously reported by us to exhibit

    ..

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Last update 4 October 2019

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