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Salvianolic acid b suppresses pyroptosis via ampk and syndecan-4 signaling pathways in human epcs

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: TANG, Yubo (Department of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University)
  • Co-author(s): Yubo Tang: Department of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
    Shuai Huang: Department of Orthopaedic Surgery, The Second Affiliated Hospital, Guangzhou Medical University, Gunagzhou, China
    Binghua Wei: Department of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
    Jie Chen: Department of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
    Xuenong Zou: Department of Orthopaedic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
    Xiao Chen: Department of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Abstract:

    Background

    Recent studies indicate that vascular endothelium is specifically sensitive to pyroptosis and autophagy mediated by endoplasmic reticulum stress (ERS), which is one of the key mechanisms causes widespread endothelial dysfunction in cardiovascular diseases. Salvianolic acid B (SalB), a natural bioactive component from Salvia miltiorrhiza, ..

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Last update 13 May 2019

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