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Determination of pka values of aminoglycoside primary amine groups by nmr spectroscopy

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: AL KHZEM, Abdulaziz (University of Bath, Pharmacy and Pharmacology)
  • Co-author(s): Abdulaziz Hassan Al Khzem: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
    Timothy Woodman: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
    Ian Blagbrough: Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
  • Abstract:

    Background

    The ionisation constant (pKa) is the pH at which functional groups are 50% ionized. Several techniques have been reported for measuring pKa values, e.g. potentiometry, Ultraviolet (UV) spectroscopy, and Nuclear Magnetic Resonance (NMR) spectroscopy. Measurement of the pKa values of any medication has a significant role in the..

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Last update 13 May 2019

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