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In-vitro &in-vivo evaluation of novel l-carnosine loaded pegylated liquid crystalline nanoparticles

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: GAAFAR, Passent (Department of Pharmaceutical Sciences, College of Pharmacy, Arab Academy for Science, Technology and Maritime transport. Alexandria, Egypt)
  • Co-author(s): Passent M. E. Gaafar Department of Pharmaceutical Sciences, College of Pharmacy, Arab Academy for Science, Technology and Maritime transport. Alexandria, Egypt.
    Ragwa M. Farid: Department of Pharmaceutical Sciences and Pharmaceutical Technology, Faculty of Pharmacy and Drug Manufacturing, Pharos university, Alexandria, Alexandria, Egypt
    Heba A. Hazzah: Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy and Drug Manufacturing, Pharos university, Alexandria, Alexandria, Egypt
    Ossama Y. Abdallah: Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
    Maged W. Helmy: Department of Pharmacology & Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt
  • Abstract:

    Background

    L-carnosine(CN) is a unique naturally occurring dipeptide anticancer drug. Several reports supported its strong anticancer activity as solution. 

    Methods

    Novel PEGylated liquid crystalline nanoparticles incorporating CN were formulated by emulsification method. Different formulation variables including; poloxamer-407, glyceryl

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Last update 13 May 2019

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