Synthesis and evaluation of 11c-labeled pyrogluamic amide derivatives as pet tracers for glial cells

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: KUMAMOTO, Takuya (Hiroshima University)
  • Co-author(s): Takuya Kumamoto: Graduate School of Biomedical & Health Sciences, Department of Synthetic Organic Chemistry, Hiroshima University, Hiroshima, Japan
    Miho Shukuri: Laboratory of Physical Chemistry, Showa Pharmaceutical University, Tokyo, Japan;Integrative Brain Imaging Center, The National Center of Neurology and Psychiatry, Tokyo, Japan
    Naoki Ihara: Integrative Brain Imaging Center, The National Center of Neurology and Psychiatry, Tokyo, Japan
    Koichi Kato: Integrative Brain Imaging Center, The National Center of Neurology and Psychiatry, Tokyo, Japan
    Takashi Hanakawa: Integrative Brain Imaging Center, The National Center of Neurology and Psychiatry, Tokyo, Japan
  • Abstract:

    Background

    P2X7 is a subtype of ATP (P2) receptors and involved in inflammatory pathways of peripheral and central nervous system (CNS). Upregulation of P2X7 receptors is observed on glial cells in CNS injury and neurodegenerative diseases. PET tracers of P2X7 receptors might be able to visualize glial cells activity and related diseases but..

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