Synthesis and evaluation of 11c-labeled pyrogluamic amide derivatives as pet tracers for glial cells

• At: Glasgow (Scotland) (2018)
• Type: Poster
• Poster code: POS-DDD-004
• By: KUMAMOTO, Takuya (Hiroshima University)
• Co-author(s): Takuya Kumamoto: Graduate School of Biomedical & Health Sciences, Department of Synthetic Organic Chemistry, Hiroshima University, Hiroshima, Japan
  Miho Shukuri: Laboratory of Physical Chemistry, Showa Pharmaceutical University, Tokyo, Japan;Integrative Brain Imaging Center, The National Center of Neurology and Psychiatry, Tokyo, Japan
  Naoki Ihara: Integrative Brain Imaging Center, The National Center of Neurology and Psychiatry, Tokyo, Japan
  Koichi Kato: Integrative Brain Imaging Center, The National Center of Neurology and Psychiatry, Tokyo, Japan
  Takashi Hanakawa: Integrative Brain Imaging Center, The National Center of Neurology and Psychiatry, Tokyo, Japan
  
• Abstract:

  Background

  P2X₇ is a subtype of ATP (P2) receptors and involved in inflammatory pathways of peripheral and central nervous system (CNS). Upregulation of P2X₇ receptors is observed on glial cells in CNS injury and neurodegenerative diseases. PET tracers of P2X₇ receptors might be able to visualize glial cells activity and related diseases but..

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