Thermo-responsive estrogen receptor-fusions for spatiotemporal control of signaling/gene regulation

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: TRUONG, Anh (University of Southern California, Pharmacology and Pharmaceutical Sciences)
  • Co-author(s): Anh Tan Truong: Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, United States
    Zhe Li: Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, United States
    Curtis Okamoto: Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, United States
    J. Andrew MacKay: Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, United States;Department of Biomedical Engineering, University of Southern California, Los Angeles, United States
  • Abstract:

    Background

    Aberrant signaling resulting as a consequence of dysregulation of the nuclear hormone estrogen receptor α (ERα) pathway has been implicated in the development of numerous diseases. Understanding how signaling and transcription occur require precise manipulation of the cells’ machinery and while small-molecule inhibitors have been

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