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Downregulation of mir-133b-5p by rest promotes prostate cancer metastasis to bone by targeting tgf-β

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Presentation
  • By: TANG, Yubo (Department of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, China)
  • Co-author(s): Yubo Tang: Department of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
    Shuai Huang: Department of Orthopaedic Surgery, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
    Dong Ren: Department of Orthopaedic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
    Peiheng He: Department of Orthopaedic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
    Xiao Chen: Department of Pharmacy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Abstract:

    Background

    High avidity of bone metastasis is an important characteristic in prostate cancer (PCa). Downexpression of miR-133b-5p has been reported to be involved in the development, progression and recurrence in PCa. However, clinical significance and biological roles of miR-133b-5p in bone metastasis of PCa remains unclear. 

    Methods

    We used

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Last update 13 May 2019

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