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Development of a pbpk model for di-2-ethylhexyl phthalate and its active metabolites, mono-2-ethylhexyl phthalate, mono-2-ethyl-5-hydroxyhexyl phthalate and mono-2-ethyl-5-oxohexyl phthalate, in rats

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: PARK, Sungwook (School of Pharmacy, Sungkyunkwan University, 수원시 장안구, Korea, Republic Of)
  • Co-author(s): Sungwook Park: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Sang Min Kim: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Tae Hwan Kim: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Junwoo Park: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Beom Soo Shin: College of Pharmacy, Catholic University of Daegu, Gyeongsan, Korea, Republic Of
    Sun Dong Yoo: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
  • Abstract:

    Background

    Di-2-ethylhexyl phthalate (DEHP) is a plasticizer used in the manufacture of a variety of common products made of PVC. The most common exposure to DEHP occurs via the oral route. Following ingestion, it is rapidly metabolized to mono-2-ethylhexyl phthalate (MEHP). MEHP is then metabolized to mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP)..

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Last update 4 October 2019

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