Integrated physiologically based pharmacokinetic modeling for dibutyl phthalate and benzyl butyl phthalate and their active metabolites, mono butyl phthalate and mono benzyl phthalate, in rats

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: PARK, Junwoo (sungkyunkwan university, suwon, Korea, Republic Of)
  • Co-author(s): Junwoo Park: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Tae Hwan Kim: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Min Gi Kim: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Sungwook Park: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Beom Soo Shin: College of Pharmacy, Catholic Univerity of Daegu, Gyeongsan, Korea, Republic Of
    Sun Dong Yoo: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
  • Abstract:

    Background

    Dibutyl phthalate (DBP) and benzyl butyl phthalate (BBP) are the plasticizers commonly used to increase the flexibility of PVCs. When orally exposed, DBP and BBP are metabolized in the gut to mono butyl phthalate (MBuP) and mono benzyl phthalate (MBzP). DBP and BBP are classified as the developmental toxicants and their metabolites are..

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