Integrated physiologically based pharmacokinetic modeling for dibutyl phthalate and benzyl butyl phthalate and their active metabolites, mono butyl phthalate and mono benzyl phthalate, in rats

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: PARK, Junwoo (sungkyunkwan university, suwon, Korea, Republic Of)
  • Co-author(s): Junwoo Park: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Tae Hwan Kim: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Min Gi Kim: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Sungwook Park: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
    Beom Soo Shin: College of Pharmacy, Catholic Univerity of Daegu, Gyeongsan, Korea, Republic Of
    Sun Dong Yoo: School of Pharmacy, Sungkyunkwan University, Suwon, Korea, Republic Of
  • Abstract:

    Methods

    This model consisted of the DBP, BBP, MBuP and MBzP components linked to where the metabolic conversion of BBP and DBP to MBzP or MBuP takes place. The pharmacokinetic parameters were obtained after intravenous injection and oral administration of BBP, DBP, MBuP and MBzP. The tissue-to-blood partition coefficients were obtained under..

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