In vitro efficiency of a formulation release from alzet® minipumps

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: LIMA, Ricardo (Bial - Portela & Cª, S.A., R&D Department, Trofa, Portugal)
  • Co-author(s): João Teixeira: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
    Teófilo Vasconcelos: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
    Patrício Soares-da-Silva: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal;MedInUP, Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal
    Ricardo Lima: R&D Department, Bial - Portela & Cª, S.A., Trofa, Portugal
  • Abstract:

    Methods

    For the in vitro pumping rate determination, filled and primed Alzet 2004 pumps®were placed into test tubes filled with isotonic saline solution, at 37 ºC. The isotonic saline solution was replaced every 24 hours, and the study was conducted for 32 days. At pre-determined time points, content released from the pumps was analyzed. To

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