Erlotinib loaded pegylated polypeptide lipid nanocapsules to enhance the anticancer efficacy in non-small cell lung cancer

  • At: 2017 FIP Congress in Seoul (South Korea)
  • Type: Poster
  • By: KIM, Jong Oh (Yeungnam University, Gyeongsan-si, Korea, Republic Of)
  • Co-author(s): Jae Hee Kim: Yeungnam University, Gyeongsan-si, Korea, Republic Of
    Jun Ho Son: Yeungnam University, Gyeongsan-si, Korea, Republic Of
    Myung-Ja Hong: Yeungnam University, Gyeongsan-si, Korea, Republic Of
    Young-Im Lee: Yeungnam University, Gyeongsan-si, Korea, Republic Of
    Dong Shik Kim: Hanyang University, Ansan-si, Korea, Republic Of
    Han-Gon Choi: Hanyang University, Ansan-si, Korea, Republic Of
    Chul Soon Yong: Yeungnam University, Gyeongsan-si, Korea, Republic Of
    Jong Oh Kim: Yeungnam University, Gyeongsan-si, Korea, Republic Of
  • Abstract:

    Methods

    pH-responsiveness and release profiles of individual drugs from drug-loaded PCM were monitored. An in vivo pharmacokinetic study of PCM (DOX-PCM and MTX-PCM) in rats and an antitumor efficacy study in A-549 cancer cell-xenografted mouse models were also performed. The effect of amine-functionalized anticancer drugs on the physicochemical..

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