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Translating Preclinical Safety Signals to the Clinic to Inform Compound Discovery and Early Development

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: METTETAL, Jay (AstraZeneca, Drug Safety and Metabolism, Waltham, United States)
  • Co-author(s): Jay Mettetal: Drug Safety and Metabolism, AstraZeneca, Waltham, United States
  • Abstract:

    Safety related findings remains a significant driver of compound attrition, particularly during late preclinical and early clinical development. A clearer picture of how early preclinical safety signals translate into man would allow a more accurate assessment potentially lowering attrition and resulting in safer drugs.

    Two common questions in

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Last update 4 October 2019

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