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Organic anion uptake of GHB at the BBB: incorporation of brain transport in modeling of PK/PD

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: MORRIS, Marilyn (University of Buffalo, Buffalo, United States)
  • Co-author(s): Marilyn Morris: Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, United States
  • Abstract:

    Organic anion transporters at the BBB facilitate the brain uptake of endogenous and exogenous organic anions, compounds typically ionized at physiological pH.  Monocarboxylate transporters (MCTs, SLC16) represent a transporter family of 14 members, identified by sequence homology, of which only the first four members (MCT1- MCT4) have been shown

    ..

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Last update 4 October 2019

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