Organic anion uptake of GHB at the BBB: incorporation of brain transport in modeling of PK/PD

• In: Symposium A2: Systems approaches to modeling the contribution of transporters in drug disposition, response and toxicity on Tuesday, 23 May 2017, 10:15-10:50
• At: Stockholm (Sweden) (2017)
• Type: Presentation
• By: MORRIS, Marilyn (University of Buffalo, Buffalo, United States)
• Co-author(s): Marilyn Morris: Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, United States
  
• Abstract:

  Organic anion transporters at the BBB facilitate the brain uptake of endogenous and exogenous organic anions, compounds typically ionized at physiological pH.  Monocarboxylate transporters (MCTs, SLC16) represent a transporter family of 14 members, identified by sequence homology, of which only the first four members (MCT1- MCT4) have been shown

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