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Dissolution/release and permeation – impact of bile

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: YAMASHITA, Shinji (Setsunan University, College of Pharmacy, Osaka, Japan)
  • Co-author(s): Shinji Yamashita: College of Pharmacy, Setsunan University, Osaka, Japan
  • Abstract:

    Food intake stimulates the secretion of bile and gives a great impact on the oral absorption of various drugs. Absorption of Class 2 drugs mostly undergoes positive food effect while that of Class 3 drugs does negative one. Since the current strategy of drug discovery often produces drug candidates with poor membrane permeability or poor


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Last update 4 October 2019

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