Uptake of cocaine, opioids and other organic cations at the blood-brain barrier
- At: 2017 FIP Congress in Stockholm (Sweden)
- Type: Presentation
- By: SCHERRMANN, Jean-Michel (University Paris Descartes, INSERM, Pharmacokinetics, PARIS, France)
- Co-author(s): Jean-Michel Scherrmann: Pharmacokinetics, University Paris Descartes, INSERM 1144, PARIS, France
Brain uptake of most psychoactive molecules is mainly believed to occur by passive diffusion although these molecules are mostly cationic at the physiological pH 7.4.
Recent studies have seriously challenged this well-established assumption following the discovery that an active uptake component may be more important that the single passive.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.