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Uptake of cocaine, opioids and other organic cations at the blood-brain barrier

  • At: 2017 FIP Congress in Stockholm (Sweden)
  • Type: Presentation
  • By: SCHERRMANN, Jean-Michel (University Paris Descartes, INSERM, Pharmacokinetics, PARIS, France)
  • Co-author(s): Jean-Michel Scherrmann: Pharmacokinetics, University Paris Descartes, INSERM 1144, PARIS, France
  • Abstract:

    Brain uptake of most psychoactive molecules is mainly believed to occur by passive diffusion although these molecules are mostly cationic at the physiological pH 7.4.

     

    Recent studies have seriously challenged this well-established assumption following the discovery that an active uptake component may be more important that the single passive

    ..

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Last update 4 October 2019

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